Introduction:

The story takes place one year after the events of Resident Evil 4. Claire Redfield is now a member of TerraSave, an organization which handles search and rescue at chemical and biological attacks. Claire arrives at Harvardville Airport to meet a family she is aiding.

A passenger aircraft is approaching the airport to land. As one of the attendants checks the passengers, she notices one man looking unwell. The man in question is clearly in the final stages of t-virus infection, and warns the attendant. Shortly after, he zombifies.

Claire is looking after her friend’s niece, Rani Chawla, when they see Senator Ron Davis walk by. While a zombie-masked protester is arrested by a police officer, only to be attacked by an actual zombie seconds later. One of Davis’ bodyguards shoots the zombie while being attacked by the infected security guard, who was presumed to be dead. The second guard attempts to run but is also devoured. The scene causes massive panic and people in the vicinity flee, some being attacked by more zombies, and the plane crashes into the building, with all of the occupants already transformed into zombies. Claire, Davis and Rani hide in the VIP lounge.

At night, the airport has been locked down by the United States Marine Corps and local law enforcement. Survivors are evacuated for treatment one at a time, many still locked inside the airport. Two Special Response Team officers, Angela Miller and Greg Glenn are joined by a government agent with experience of such incidents, Leon S. Kennedy. The group enters the building through the roof and begin their search. Leon keeps an eye on the team, who are untrained in handling zombies, and manages to find Claire and the survivors. During the escape back to the main terminal, Greg is bitten by a zombie and stays behind, determined to save the rest by killing the creatures nearby. The survivors shoot their way through the exit and manage to evacuate the terminal, with the Marines clearing out the terminal.